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Inside our research, we were in the position to considerably escalate the dose of CX-5461 beyond that realized in the 1st-in-human examine in people with hematologic cancers. The RP2D of 475 mg/m2 on times one, 8, and 15 of a 4-7 days cycle, was according to phototoxicity, which transpired Irrespective of rigid UV light-weight avoidance protocols